Diphenhydramine Hcl Tablet, Coated
NDC Package 51316-221-08

The code 51316-221-08 identifies a specific commercial package of 2 blister pack in 1 carton / 12 tablet, coated in 1 blister pack of Diphenhydramine Hcl, a human over the counter drug labeled by Cvs Pharmacy, Inc.. This tablet, coated is formulated for oral use and contains diphenhydramine hydrochloride as the active substance.

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Cvs Pharmacy, Inc. on January 31, 2024. The current certification is valid through December 31, 2026.

Diphenhydramine injection is an antihistamine used to treat life-threatening allergic reactions (anaphylaxis) along with epinephrine and other treatments. It is also used to relieve symptoms of household allergies, hay fever and the common cold when medication cannot be given by mouth. Common allergy symptoms relieved by antihistamines include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose and sneezing. It is also used to treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth. Diphenhydramine works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine). Diphenhydramine should not be used in newborns or premature infants because of an increased risk of side effects. It should not be used for common cold symptoms in children less than 6 years of age due to the risk of serious side effects, such as slow/shallow breathing. Cough-and-cold products have not been shown to be safe or effective in children younger than 6.

For medical billing and reimbursement, this package follows the 11-digit CMS format: 51316022108. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.