Cvs Childrens Nighttime Multi Symptom Cold Liquid
NDC Package 51316-733-04

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. Frequently Asked Questions

Package Information

Cvs Childrens Nighttime Multi Symptom Cold (acetaminophen , diphenhydramine hydrochloride, phenylephrine hydrochloride) liquids is ▪this product does not contain directions or complete warnings for adult use▪do not give more than directed (see Overdose warning)▪measure only with dosing cup provided ▪do not use dosing cup with other products▪dose as follows or as directed by a doctor▪children 6 years to 12 years of age: 10 mL in dosing cup provided every 4 hours while symptoms last; do not give more than 5 doses in 24-hours period▪children under 6 years of age: do not use. This formulation utilizes a liquid delivery system. Marketed by Cvs Pharmacy, this product is identified by NDC 51316-733 and is authorized under FDA application M010.

Identification & Billing

NDC Package Code
51316-733-04
Package Description
118 mL in 1 BOTTLE
Product Code
51316-733
11-Digit Billing Format
51316073304
Billing Unit
C73365
RxNorm Crosswalk
  • RxCUI: 1375932 - acetaminophen 650 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 10 MG in 20 mL Oral Solution
  • RxCUI: 1375932 - acetaminophen 32.5 MG/ML / diphenhydramine hydrochloride 1.25 MG/ML / phenylephrine hydrochloride 0.5 MG/ML Oral Solution
  • RxCUI: 1375932 - acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 10 ML Oral Solution
  • RxCUI: 1375932 - acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 20 ML Oral Solution
  • RxCUI: 1375932 - APAP 32.5 MG/ML / Diphenhydramine Hydrochloride 1.25 MG/ML / Phenylephrine Hydrochloride 0.5 MG/ML Oral Solution

Clinical Specifications

Proprietary Name
Cvs Childrens Nighttime Multi Symptom Cold
Non-Proprietary Name
Acetaminophen , Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride
Substance Name
Acetaminophen; Diphenhydramine Hydrochloride; Phenylephrine Hydrochloride
Dosage Form
Liquid - A dosage form consisting of a pure chemical in its liquid1 state. This dosage form term should not be applied to solutions.
Administration Route
Oral - Administration to or by way of the mouth.
Active Ingredient(s)
Pharmacologic Class
Usage Information
▪this product does not contain directions or complete warnings for adult use▪do not give more than directed (see Overdose warning)▪measure only with dosing cup provided ▪do not use dosing cup with other products▪dose as follows or as directed by a doctor▪children 6 years to 12 years of age: 10 mL in dosing cup provided every 4 hours while symptoms last; do not give more than 5 doses in 24-hours period▪children under 6 years of age: do not use

Regulatory & Marketing

Labeler Name
Cvs Pharmacy
Product Type
Human Otc Drug
FDA Application #
M010
Marketing Category
OTC MONOGRAPH DRUG -
Start Marketing Date
02-20-2023
Listing Expiration
12-31-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 51316-733-04 identifies a specific commercial package of 118 ml in 1 bottle of Cvs Childrens Nighttime Multi Symptom Cold, a human over the counter drug labeled by Cvs Pharmacy. This liquid is formulated for oral use and contains acetaminophen; diphenhydramine hydrochloride; phenylephrine hydrochloride as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Cvs Pharmacy on February 20, 2023. The current certification is valid through December 31, 2026.

How is this Cvs Pharmacy product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 51316073304. Quantities are measured in C73365. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-3-2)
51316-733-04
11-Digit CMS (5-4-2)
51316-0733-04

Note: The zero is added to the Product segment to maintain the 5-4-2 structure.