2.1 Important Administration Instructions
10% Dextrose Injection is intended for intravenous use.
Peripheral administration of 5% dextrose is generally acceptable, however, consider central vein when administering more than 5% dextrose or with an osmolarity of at least 900 mOsm/L or when there is peripheral vein irritation, phlebitis, and/or associated pain [see Warnings and Precautions (5.3)].
Do not administer 10% Dextrose Injection simultaneously with blood products through the same administration set because of the possibility of pseudoagglutination or hemolysis.
To prevent air embolism, use a non-vented infusion set or close the vent on a vented set, avoid multiple connections, do not connect flexible containers in series, fully evacuate residual gas in the container prior to administration, do not pressurize the flexible container to increase flow rates, and if administration is controlled by a pumping device, turn off pump before the container runs dry.
Prior to infusion, visually inspect the diluted dextrose solution for particulate matter. The solution should be clear and there should be no precipitates. Do not administer unless solution is clear and container is undamaged.
Use of a final filter is recommended during administration of parenteral solutions, where possible.
2.2 Recommended Dosage
The choice of dextrose concentration, rate and volume depends on the age, weight, clinical and metabolic conditions of the patient and concomitant therapy. Electrolyte supplementation may be indicated according to the clinical needs of the patient.
The administration rate should be governed, especially for premature infants with low birth weight, during the first few days of therapy, by the patient's tolerance to dextrose.
Increase the infusion rate gradually as indicated by frequent monitoring of blood glucose concentrations [see Warnings and Precautions (5.1), Use in Specific Populations (8.4)].
2.3 Instructions for Use
Check flexible container solution composition, lot number, and expiry date. Prior to administration, visually inspect for particulate matter and discoloration.
The intact port caps provides visual tamper evidence. Do not use if a port cap is prematurely removed. Do not remove solution container from its overwrap until immediately before use. Use sterile equipment and aseptic technique.
To Open
Place the solution container on a clean, flat surface. Using the pre-cut corner tabs, peel open the overwrap and remove solution container.
Check the solution container for leaks by squeezing firmly. If leaks are found, or if the seal is not intact, discard the solution.
Do not use if the solution is cloudy or a precipitate is present.
To Add Medication
Identify WHITE Additive Port with arrow pointing toward container.
Immediately before injecting additives, break off WHITE Additive Port Cap with the arrow pointing toward container.
Hold base of WHITE Additive Port horizontally.
Insert needle (18 to 23 gauge) horizontally through the center of WHITE Additive Port's septum and inject additives.
Mix container contents thoroughly. For high density medication such as potassium chloride, squeeze ports while ports are upright and mix thoroughly.
Preparation for Administration
Immediately before inserting the infusion set, break off BLUE Infusion Port Cap with the arrow pointing away from container.
Use a non-vented infusion set or close the air-inlet on a vented set.
Close the roller clamp of the infusion set.
Hold the base of BLUE Infusion Port.
Insert spike through BLUE Infusion Port by rotating wrist slightly until the spike is inserted.
Suspend solution container from hanger hole
For Single Use Only. Discard unused portion.
NOTE: See full directions accompanying administration set.
WARNING: Do not use flexible container in series connections.
