Xyosted Injection
Pricing Report NDC 54436-250-04

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Xyosted (NDC 54436-250-04) is $315.31826 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Antares Pharma, Inc., this medication is distributed in a 4 SYRINGE in 1 CARTON / .5 mL in 1 SYRINGE (54436-250-02) configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$315.31826
Per ML

Effective Date
Jun 17, 2026
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
4 SYRINGE in 1 CARTON / .5 mL in 1 SYRINGE (54436-250-02)
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Sep 2021, the NADAC wholesale price for (NDC ) has moved within a range of $265.44571 to $316.74082 per ML. Over this 4 years and 8 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$265.4457 - $316.7408
Market Volatility
19.32% Variance
Latest Trend
0.05%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $315.31826 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 20, 2026 $315.47924 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 01, 2026 $316.74082 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2026 $316.74082 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2026 $316.74082 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 17, 2025 $307.51237 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 19, 2025 $307.51431 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $307.48156 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 17, 2025 $307.46595 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 20, 2025 $307.26530 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 23, 2025 $307.22740 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 18, 2025 $307.05988 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 21, 2025 $306.90268 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 06, 2025 $307.96360 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 06, 2025 $307.96360 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 06, 2025 $307.96360 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 18, 2024 $298.99379 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 20, 2024 $299.00131 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 23, 2024 $298.91197 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 18, 2024 $299.00983 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 21, 2024 $299.10357 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 17, 2024 $298.99886 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 19, 2024 $298.51871 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2024 $298.60260 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 04, 2024 $298.90703 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 04, 2024 $298.90703 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 04, 2024 $298.90703 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 18, 2023 $290.19818 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 18, 2023 $290.19818 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 03, 2023 $292.64832 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 03, 2023 $292.64832 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 03, 2023 $292.64832 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jul 01, 2022 $278.71534 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2022 $278.71534 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2022 $278.71534 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Sep 22, 2021 $265.44571 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 22, 2021 $265.44571 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Sep 22, 2021 $265.44571 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026