Xyosted Injection
Pricing Report NDC 54436-275-04

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Xyosted (NDC 54436-275-04) is $316.49380 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Antares Pharma, Inc., this medication is distributed in a 4 SYRINGE in 1 CARTON / .5 mL in 1 SYRINGE (54436-275-02) configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$316.49380
Per ML

Effective Date
Jun 17, 2026
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
4 SYRINGE in 1 CARTON / .5 mL in 1 SYRINGE (54436-275-02)
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since May 2019, the NADAC wholesale price for (NDC ) has moved within a range of $226.52000 to $316.84680 per ML. Over this 7 years period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$226.5200 - $316.8468
Market Volatility
39.88% Variance
Latest Trend
0.06%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $316.49380 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 20, 2026 $316.68394 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 01, 2026 $316.84680 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2026 $316.84680 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2026 $316.84680 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 17, 2025 $307.61526 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 19, 2025 $307.58515 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $307.60444 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 17, 2025 $307.57498 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 20, 2025 $307.58142 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 23, 2025 $307.45053 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 18, 2025 $307.38171 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 21, 2025 $307.35489 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 06, 2025 $308.12939 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 06, 2025 $308.12939 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 06, 2025 $308.12939 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 18, 2024 $299.15475 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 20, 2024 $299.27058 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 23, 2024 $299.35206 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 18, 2024 $299.54528 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 21, 2024 $299.49895 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 17, 2024 $299.49852 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 19, 2024 $299.44816 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2024 $299.89119 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 04, 2024 $298.50913 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 04, 2024 $298.50913 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 04, 2024 $298.50913 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 18, 2023 $289.81188 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 18, 2023 $289.81188 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 03, 2023 $291.22215 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 03, 2023 $291.22215 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 03, 2023 $291.22215 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jul 01, 2022 $277.35707 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2022 $277.35707 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2022 $277.35707 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Apr 20, 2022 $264.15211 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Apr 20, 2022 $264.15211 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2021 $262.66090 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2021 $262.66090 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2021 $262.66090 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 21, 2020 $250.15563 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 21, 2020 $250.15563 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2020 $252.15068 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2020 $252.15068 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2020 $252.15068 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Mar 18, 2020 $240.14808 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Mar 18, 2020 $240.14808 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2019 $237.84600 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2019 $237.84600 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2019 $237.84600 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
May 22, 2019 $226.52000 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2019 $226.52000 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026