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Bacitracin Zinc and Polymyxin B Sulfate Ophthalmic Ointment is a
sterile antimicrobial ointment for ophthalmic use.Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic
polypeptides (mainly bacitracin A) produced by the growth of an organism of the
licheniformis group of Bacillus subtilis var Tracy.
It has a potency of not less than 40 bacitracin units per mg. The structural
formula for bacitracin A is:Polymyxin B Sulfate is the sulfate salt of polymyxin B1 and B2 which are produced by the
growth of Bacillus polymyxa (Prazmowski) Migula (Fam.
Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg,
calculated on an anhydrous basis. The structural formulae are:Each gram contains: Bacitracin zinc equal to 500 bacitracin units and
polymyxin B sulfate equal to 10,000 polymyxin B units, white petrolatum and
Polymyxin B attacks gram-negative bacilli, including virtually
all strains of Pseudomonas aeruginosa and H influenzae species.Bacitracin is active against most gram-positive bacilli and cocci including
Indications And Usage
For the treatment of superficial ocular infections involving the
conjunctiva and/or cornea caused by organisms susceptible to bacitracin zinc and
polymyxin B sulfate.
This product is contraindicated in those individuals who have
shown hypersensitivity to any of its components.
Ophthalmic ointments may retard corneal healing.
As with other antibiotic preparations, prolonged use may result
in overgrowth of nonsusceptible organisms, including fungi. Appropriate measures
should be taken if this occurs.
Dosage And Administration
Apply the ointment every 3 or 4 hours for 7 to 10 days, depending
on the severity of the infection.
Bacitracin Zinc and Polymyxin B Sulfate ophthalmic ointment USP,
sterile, each gram contains bacitracin zinc equal to 500 bacitracin units and
polymyxin B sulfate equal to 10,000 polymyxin B units, in a tube of 3.5 g (1/8
oz) with ophthalmic tip.NDC 54868-1199-0
Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room
Temperature].Manufactured By: Akorn, Inc.Lake Forest, IL 60045AKP00NRev. 11/08Relabeling of "Additional Barcode Label" by:Physicians Total Care, Inc.Tulsa, OK 74146
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