Product Images Venlafaxine Hydrochloride

This is a report of drug interactions and their effects on Analyte (possibly a drug or chemical compound). The interacting drugs include Ethanol, Diazepam, Cimetidine, Ketoconazole, Indinavir, Metoprolol, Imipramine, and Lithium. The effects of these interactions are measured in terms of PK (pharmacokinetics) fold change and 90% CI recommendation. The report provides recommendations for the clinical use of these drugs, including avoiding concomitant use, using with caution in patients with hypertension, elderly, or hepatic dysfunction, and monitoring blood pressure.*

This is a list of drugs and their interaction with other drugs. There are recommended actions like avoiding concomitant use, using caution or not adjusting the dose. The clinical significance of some interactions is unknown. There are also references to maximum concentration and area under the curve.*

This text provides recommendations for dosage adjustments of venlafaxine (a medication used to treat depression) for patients with hepatic cirrhosis, mild/moderate hepatic impairment, renal impairment, CYP2D6 polymorphism, age, and gender. The recommendations vary depending on the analyte PK fold change and a 90% confidence interval. Dosage reductions ranging from 25% to 50% are suggested for most conditions, except for hepatic cirrhosis and renal impairment where the recommended dosage reduction is 50% or greater. The text also includes information about the change relative to the reference value.*