Enbrel Solution
Pricing Report NDC 58406-021-04

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Enbrel (NDC 58406-021-04) is $2080.75244 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Immunex Corporation, this medication is distributed in a 4 SYRINGE in 1 CARTON / 1 mL in 1 SYRINGE (58406-021-01) configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$2,080.75244
Per ML

Effective Date
Jun 17, 2026
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
4 SYRINGE in 1 CARTON / 1 mL in 1 SYRINGE (58406-021-01)
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Dec 2019, the NADAC wholesale price for (NDC ) has moved within a range of $1,260.65983 to $2,080.75244 per ML. Over this 6 years and 5 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$1,260.6598 - $2,080.7524
Market Volatility
65.05% Variance
Latest Trend
No Change
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $2080.75244 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 20, 2026 $2080.70983 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 07, 2026 $2080.74231 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 07, 2026 $2080.74231 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 07, 2026 $2080.74231 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 17, 2025 $1981.65935 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 19, 2025 $1981.61250 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $1981.26291 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 17, 2025 $1980.96690 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 20, 2025 $1980.81297 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 23, 2025 $1981.35924 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 18, 2025 $1980.94068 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 21, 2025 $1981.76000 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 08, 2025 $1981.42601 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 08, 2025 $1981.42601 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 08, 2025 $1981.42601 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Aug 23, 2024 $1851.80001 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Aug 23, 2024 $1851.80001 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Aug 23, 2024 $1851.80001 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Aug 21, 2024 $1797.86409 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 17, 2024 $1797.92000 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 19, 2024 $1798.30836 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2024 $1796.82250 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 05, 2024 $1800.82312 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 05, 2024 $1800.82312 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 05, 2024 $1800.82312 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jan 04, 2023 $1715.06964 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 04, 2023 $1715.06964 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 04, 2023 $1715.06964 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jul 01, 2022 $1596.89910 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jul 01, 2022 $1596.89910 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2022 $1596.89910 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jan 26, 2022 $1559.47178 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 26, 2022 $1559.47178 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 26, 2022 $1559.47178 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Nov 17, 2021 $1452.02214 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 17, 2021 $1452.02214 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 22, 2021 $1452.84867 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 22, 2021 $1452.84867 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 22, 2021 $1452.84867 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 21, 2020 $1352.74550 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 21, 2020 $1352.74550 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 17, 2020 $1353.94866 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 17, 2020 $1353.94866 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 17, 2020 $1353.94866 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 18, 2019 $1260.65983 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Dec 18, 2019 $1260.65983 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026