Guaifenesin Liquid
Pricing Report NDC 58657-509-16

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Guaifenesin (NDC 58657-509-16) is $0.01334 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jan 21, 2026.

As a a human over the counter drug provided by Method Pharmaceuticals, Llc, this medication is distributed in a 473 mL in 1 BOTTLE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$0.01334
Per ML

Effective Date
Jan 21, 2026
Billable Units
473 ML
Estimated Package Price
$6.31
Data Status
As of Jan 28, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
473 mL in 1 BOTTLE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jul 2016, the NADAC wholesale price for (NDC ) has moved within a range of $0.00499 to $0.01538 per ML. Over this 9 years and 6 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$0.0050 - $0.0154
Market Volatility
208.22% Variance
Latest Trend
1.06%
Date Unit Price Unit Source Method Rate
Jan 21, 2026 $0.01334 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $0.01320 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $0.01277 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $0.01335 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2025 $0.01280 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2025 $0.01333 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 23, 2025 $0.01297 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2025 $0.01330 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2025 $0.01258 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 23, 2025 $0.01249 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 19, 2025 $0.01229 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2025 $0.01229 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2025 $0.01169 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2024 $0.01158 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2024 $0.01126 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2024 $0.01159 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2024 $0.01218 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2024 $0.01222 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $0.00889 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $0.01314 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $0.01033 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $0.01259 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2024 $0.01407 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 21, 2024 $0.01272 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 17, 2024 $0.01378 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $0.01165 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 22, 2023 $0.01191 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $0.01340 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2023 $0.01326 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2023 $0.01352 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 19, 2023 $0.01188 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 21, 2023 $0.01141 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2023 $0.01312 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 19, 2023 $0.01277 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $0.01434 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 22, 2023 $0.01508 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2023 $0.01121 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2022 $0.01195 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2022 $0.01209 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2022 $0.01013 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2022 $0.01057 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $0.00949 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $0.00949 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jun 22, 2022 $0.00901 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2022 $0.00927 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2022 $0.00988 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 23, 2022 $0.00969 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 23, 2022 $0.00932 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 19, 2022 $0.00939 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 22, 2021 $0.01174 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 17, 2021 $0.01282 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 20, 2021 $0.01006 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 22, 2021 $0.01008 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 18, 2021 $0.01361 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 21, 2021 $0.01161 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 23, 2021 $0.01377 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 19, 2021 $0.00978 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 21, 2021 $0.00905 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 17, 2021 $0.01051 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 17, 2021 $0.01036 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 20, 2021 $0.01538 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 23, 2020 $0.01459 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 18, 2020 $0.01216 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 21, 2020 $0.01067 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 23, 2020 $0.00828 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 19, 2020 $0.00845 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2020 $0.00725 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2020 $0.00905 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2020 $0.00974 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2020 $0.00764 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2020 $0.00700 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2020 $0.00907 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2020 $0.00774 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2019 $0.00666 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2019 $0.00792 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2019 $0.00684 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2019 $0.00669 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2019 $0.00651 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2019 $0.00607 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2019 $0.00704 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2019 $0.00768 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2019 $0.00592 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2019 $0.00524 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 20, 2019 $0.00532 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 23, 2019 $0.00530 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 19, 2018 $0.00524 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 21, 2018 $0.00535 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 17, 2018 $0.00520 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 19, 2018 $0.00510 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 22, 2018 $0.00543 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 18, 2018 $0.00552 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 20, 2018 $0.00519 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 23, 2018 $0.00567 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 18, 2018 $0.00563 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 21, 2018 $0.00550 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 21, 2018 $0.00555 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 17, 2018 $0.00532 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2017 $0.00558 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 22, 2017 $0.00562 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2017 $0.00565 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2017 $0.00558 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2017 $0.00545 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 19, 2017 $0.00583 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 21, 2017 $0.00508 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2017 $0.00567 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 19, 2017 $0.00572 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2017 $0.00553 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 22, 2017 $0.00551 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2017 $0.00522 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2016 $0.00518 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2016 $0.00499 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2016 $0.00538 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2016 $0.00600 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2016 $0.00591 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2016 $0.00601 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 13, 2016 $0.00558 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026