Promethazine Hydrochloride And Dextromethorphan Hydrobromide Solution
Pricing Report NDC 65162-680-90

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Promethazine Hydrochloride And Dextromethorphan Hydrobromide (NDC 65162-680-90) is $0.03834 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Amneal Pharmaceuticals Llc, this medication is distributed in a 473 mL in 1 BOTTLE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$0.03834
Per ML

Effective Date
Jun 17, 2026
Billable Units
473 ML
Estimated Package Price
$18.13
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
473 mL in 1 BOTTLE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since May 2020, the NADAC wholesale price for (NDC ) has moved within a range of $0.02052 to $0.06864 per ML. Over this 6 years and 1 month period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$0.0205 - $0.0686
Market Volatility
234.50% Variance
Latest Trend
0.47%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $0.03834 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2026 $0.03852 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2026 $0.03887 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2026 $0.03933 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2026 $0.04068 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2026 $0.04253 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $0.04377 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $0.04350 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $0.04330 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2025 $0.04281 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2025 $0.04459 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 23, 2025 $0.05103 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 23, 2025 $0.05103 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jul 23, 2025 $0.04573 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2025 $0.05116 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2025 $0.04867 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2025 $0.05120 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2025 $0.04870 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 23, 2025 $0.05129 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 23, 2025 $0.04702 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 19, 2025 $0.05129 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 19, 2025 $0.04345 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2025 $0.05073 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2025 $0.03869 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2025 $0.04852 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2025 $0.03440 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2024 $0.04932 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2024 $0.03452 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2024 $0.04465 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2024 $0.02931 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2024 $0.05370 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2024 $0.04132 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2024 $0.04635 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2024 $0.04318 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2024 $0.04188 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2024 $0.04149 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $0.03594 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $0.03767 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $0.04102 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $0.04112 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $0.03935 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $0.03893 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $0.03952 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $0.03868 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2024 $0.06259 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2024 $0.04395 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 21, 2024 $0.06338 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 21, 2024 $0.04393 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 17, 2024 $0.05820 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 17, 2024 $0.04287 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $0.06644 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $0.04139 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 22, 2023 $0.06467 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 22, 2023 $0.04382 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $0.06174 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $0.03906 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2023 $0.06039 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2023 $0.04154 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2023 $0.05895 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2023 $0.04257 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 19, 2023 $0.06062 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 19, 2023 $0.04426 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 21, 2023 $0.06263 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 21, 2023 $0.04439 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2023 $0.06283 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2023 $0.04347 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 19, 2023 $0.05792 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 19, 2023 $0.03982 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $0.06618 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $0.04428 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 22, 2023 $0.05731 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 22, 2023 $0.04352 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2023 $0.06255 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2023 $0.04717 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2022 $0.04601 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2022 $0.04788 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2022 $0.06130 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2022 $0.06130 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Oct 19, 2022 $0.05098 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2022 $0.06368 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2022 $0.04909 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2022 $0.05533 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $0.06601 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $0.06601 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jul 20, 2022 $0.05382 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2022 $0.06058 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2022 $0.05533 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2022 $0.06173 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2022 $0.05849 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2022 $0.06864 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2022 $0.06124 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 23, 2022 $0.05718 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 23, 2022 $0.05643 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 23, 2022 $0.06529 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 23, 2022 $0.05549 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 19, 2022 $0.06410 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 19, 2022 $0.05733 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 22, 2021 $0.05706 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 17, 2021 $0.05771 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 20, 2021 $0.05757 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 22, 2021 $0.06037 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 18, 2021 $0.06208 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 21, 2021 $0.06204 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 23, 2021 $0.06316 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 19, 2021 $0.06497 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 21, 2021 $0.06318 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 17, 2021 $0.06490 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 17, 2021 $0.06665 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 20, 2021 $0.06480 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 23, 2020 $0.06522 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 18, 2020 $0.06686 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 21, 2020 $0.06658 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 23, 2020 $0.06520 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 19, 2020 $0.06504 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2020 $0.06530 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2020 $0.06278 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2020 $0.06435 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 06, 2020 $0.02052 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
May 06, 2020 $0.06272 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026