Dotti Patch, Extended Release
Product Images NDC 65162-997

Product Visual Gallery

This gallery contains 26 technical images submitted to the FDA as part of the official labeling for Dotti (NDC 65162-997). Unlike standard consumer photos, these assets often include clinical data figures, molecular chemical structures, and official manufacturer packaging layouts.

As provided by Amneal Pharmaceuticals Llc, these visuals offer a comprehensive scientific overview of the product's physical and chemical identity, aiding pharmacists and researchers in product verification and study.

FDA Label Image

1 (Dotti Estradiol Transdermal System 1)

Chemical structure diagram of estradiol, the active ingredient in DOTTI patches. The structure shows four interconnected carbon rings with hydroxyl groups attached, characteristic of the estradiol molecule.*

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4a (Dotti Estradiol Transdermal System 10)

An illustration showing hands applying a rectangular transdermal patch, representing the use instructions for DOTTI Estradiol extended release patch. It visually demonstrates how to handle and apply the patch to the skin.*

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4b (Dotti Estradiol Transdermal System 11)

An instructional illustration showing two hands peeling apart a protective backing from a DOTTI transdermal patch, designed for extended-release delivery of estradiol. The image demonstrates the patch preparation or application step for this human prescription drug by Amneal Pharmaceuticals LLC.*

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4c (Dotti Estradiol Transdermal System 12)

An illustration showing a hand holding a small circular transdermal patch near a person's abdominal area, depicting the application process of a DOTTI estradiol extended-release transdermal patch.*

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4d (Dotti Estradiol Transdermal System 13)

An instructional illustration showing hands applying a DOTTI estradiol transdermal patch to the skin. The image demonstrates how to place and press the patch firmly for proper adhesion.*

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4e (Dotti Estradiol Transdermal System 14)

An instructional illustration showing hands applying a transdermal patch to the skin. One hand holds the patch while the other smooths it onto the skin, demonstrating the application process for a patch drug delivery system.*

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4f (Dotti Estradiol Transdermal System 15)

An instructional illustration showing the application of a DOTTI estradiol transdermal extended-release patch on the skin of the forearm near the wrist.*

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4g (Dotti Estradiol Transdermal System 16)

An instructional illustration showing a finger pressing a round transdermal skin patch onto a person's skin, likely demonstrating application of the DOTTI estradiol extended-release patch.*

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0.025 mg/day Pouch (Dotti Estradiol Transdermal System 17)

Label for DOTTI estradiol transdermal system patch delivering 0.025 mg/day estradiol. The label indicates the patch size as 0.75 x 2.5 inches and mentions it is for twice weekly use. The labeler is Amneal Pharmaceuticals LLC, with NDC 65162-989-04. It includes usage instructions, inactive ingredients, storage conditions, and barcode.*

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0.025 mg/day Carton (Dotti Estradiol Transdermal System 18)

DOTTI 0.025 mg/day estradiol transdermal system patch carton from Amneal Pharmaceuticals LLC. The packaging indicates it is a prescription drug delivering 0.025 mg of estradiol daily via a twice-weekly transdermal patch system. The carton includes patient instructions for patch use and storage information, along with the NDC 65162-989-08 and note that it contains 8 systems.*

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0.0375 mg/day Pouch (Dotti Estradiol Transdermal System 19)

DOTTI (estradiol transdermal system USP) 0.0375 mg/day adhesive patch label from Amneal Pharmaceuticals LLC. The label details the patch size, inactive ingredients, usage instructions for twice-weekly application, storage conditions, and barcode. The patch measures 0.75 by 2.5 inches and includes lot and expiration number areas.*

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2 (Dotti Estradiol Transdermal System 2)

An illustration showing the three-layer structure of the DOTTI estradiol extended-release transdermal patch. The layers include (1) backing, (2) adhesive containing estradiol, and (3) protective liner.*

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0.0375 mg/day Carton (Dotti Estradiol Transdermal System 20)

DOTTI estradiol transdermal system, USP patch delivers 0.0375 mg/day, in a carton by Amneal Pharmaceuticals LLC. The packaging is white with gray and black text, showing patient instructions for use, storage information, and includes 8 systems. It is labeled for prescription use only and indicates twice-weekly application. Barcodes and NDC numbers are present.*

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0.05 mg/day Pouch (Dotti Estradiol Transdermal System 21)

DOTTI estradiol transdermal system patch delivering 0.05 mg/day dosage. The label details each patch size as 0.75 by 2.5 inches and notes administration twice weekly. It includes inactive components such as acrylic adhesive and silicone adhesive. Distributed by Amneal Pharmaceuticals LLC, the packaging also shows lot and expiration fields and a barcode on the right side.*

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0.05 mg/day Carton (Dotti Estradiol Transdermal System 22)

DOTTI (estradiol transdermal system, USP) delivers 0.05 mg/day in a twice-weekly patch form. The unfolded carton displays dosing and patient instructions, manufacturer Amneal Pharmaceuticals LLC, and a barcode. It specifies contents of 8 systems and the transdermal route of administration.*

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0.075 mg/day Pouch (Dotti Estradiol Transdermal System 23)

DOTTI estradiol transdermal system patch delivering 0.075 mg/day. The label states one 5.66 cm² patch contains 0.940 mg estradiol and includes inactive ingredients such as acrylic adhesives and polyester liner. It is a twice-weekly prescription patch from Amneal Pharmaceuticals LLC, with storage instructions and regulatory compliance information.*

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0.075 mg/day Carton (Dotti Estradiol Transdermal System 24)

Packaging label for DOTTI (estradiol transdermal system, USP) patch delivering 0.075 mg/day. The label shows it is a twice-weekly, extended-release transdermal patch manufactured by Amneal Pharmaceuticals LLC. The label includes patient instructions for patch application and disposal, contents of 8 systems, and the NDC number 65162-995-08.*

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0.1 mg/day Pouch (Dotti Estradiol Transdermal System 25)

DOTTI (estradiol transdermal system, USP) delivers 0.1 mg/day in a 7.55 cm² patch labeled for twice weekly use. The label details each system containing 1.253 mg estradiol, with silicone adhesive and multiple polymer layers. It is manufactured and distributed by Amneal Pharmaceuticals LLC, Bridgewater, NJ. The label includes storage instructions and a barcode.*

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0.1 mg/day Carton (Dotti Estradiol Transdermal System 26)

DOTTI 0.1 mg/day estradiol transdermal system package label showing a twice-weekly patch by Amneal Pharmaceuticals LLC. The carton includes patient instructions for patch application and discard, ingredient and packaging details, and a barcode. The label highlights the patch strength and usage frequency on a white and yellow background.*

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Figure 1 (Dotti Estradiol Transdermal System 3)

A line graph showing concentration (pg/mL) versus time (days) for four different dosage strengths of DOTTI estradiol transdermal patches: 0.03/5, 0.05, 0.075, and 0.1 mg/day. The graph depicts changes in concentration levels over a 4-day period for each strength.*

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2 (Dotti Estradiol Transdermal System 4)

A bar graph comparing the mean reduction from baseline between Estradiol 0.0375 mg/day patches and placebo at weeks 4, 8, and 12. The y-axis shows the mean reduction with standard deviation, and Estradiol bars demonstrate greater reduction than placebo bars at all time points. Sample sizes are indicated below each bar.*

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2 (Dotti Estradiol Transdermal System 5)

A line graph showing percent change from baseline over treatment duration in weeks (26, 52, 78, 104) for different doses of Estradiol patches (0.1, 0.05, 0.0375, 0.025 mg/day) compared to placebo. Each dose is represented with distinct line styles and markers, with higher doses showing greater positive change over time.*

FDA Label Image

1 (Dotti Estradiol Transdermal System 6)

A line graph depicting the percentage change from baseline over treatment durations of 26, 52, 78, and 104 weeks. The graph compares Estradiol patches at dosages of 0.1 mg/day, 0.05 mg/day, 0.0375 mg/day, 0.025 mg/day, and a placebo group. Statistical significance in comparison to placebo is indicated at various time points.*

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1 (Dotti Estradiol Transdermal System 7)

Illustration for DOTTI estradiol transdermal system showing a checklist to help users track patch change days. It lists paired days of the week for patch replacement: Sun/Wed, Mon/Thu, Tue/Fri, Wed/Sat, Thu/Sun, Fri/Mon, and Sat/Tue.*

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2 (Dotti Estradiol Transdermal System 8)

An instructional illustration showing a hand applying a small, circular transdermal patch to the lower abdominal area of a person. The image demonstrates the correct placement of the DOTTI estradiol extended-release patch on the skin for transdermal administration.*

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3 (Dotti Estradiol Transdermal System 9)

DOTTI estradiol transdermal extended-release patch, displaying a single rectangular patch with a slightly contoured edge visible. The patch is white with a faint outline and minimal markings.*

* About these descriptions: Image descriptions on this page are generated by automated AI analysis of the product label images from the manufacturer's FDA label submission (SPL). They are provided for reference only and may contain errors or omissions. Always rely on the printed label itself and the official FDA labeling, and consult a pharmacist or healthcare professional with any questions about this product.