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Desogestrel ethinyl estradiol is a combination of two hormonal medications used as a contraceptive pill for women. It contains desogestrel, a synthetic progesterone, and ethinyl estradiol, a synthetic estrogen. This pill works by inhibiting ovulation and changing the cervical mucus and uterine lining, making it harder for sperm to reach the uterus and for a fertilized egg to implant.*