Description
DESCRIPTION
Rimantadine hydrochloride is a synthetic antiviral drug available as a 100 mg film-coated tablet. Each film-coated tablet contains 100 mg of rimantadine hydrochloride. In addition, each tablet contains the following inactive ingredients: hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, purified water, sodium starch glycolate and FDandC Yellow No. 6 Lake. Film coating material, Opadry (YS-1-19025-A), contains hypromellose and macrogol.
Rimantadine hydrochloride is a white to off-white crystalline powder which is freely soluble in water (50 mg/mL at 20°C). Chemically, rimantadine hydrochloride is alpha-methyltricyclo-[3.3.1.1/3.7]decane-1-methanamine hydrochloride, with an empirical formula of C12H21N•HCl, a molecular weight of 215.77 and the following structural formula:
Rimantadine Hydrochloride Formula (Rimantadinehydrochlorideformula)
PRODUCT DESCRIPTION Primary Ingredients Lister-V consists of a proprietary blend of amino acids, cocoa, caffeine, cinnamon, and flavonoids in specific proportions. These ingredients fall into the category of “Generally Regarded as Safe” (GRAS) as defined by the Food and Drug Administration (FDA) (Sections 201(s) and 409 of the Federal Food, Drug, and Cosmetic Act). A GRAS substance is distinguished from a food additive on the basis of the common knowledge about the safety of the substance for its intended use. The standard for an ingredient to achieve GRAS status requires not only technical demonstration of non-toxicity and safety, but also general recognition of safety through widespread usage and agreement of that safety by experts in the field. Many ingredients have been determined by the U.S. Food and Drug Administration (FDA) to be GRAS, and are listed as such by regulation, in Volume 21 Code of Federal Regulations (CFR) Sections 182, 184, and 186. Amino Acids Amino Acids are the building blocks of protein. All amino acids are GRAS listed as they have been ingested by humans for thousands of years. The doses of the amino acids in Lister-V are equivalent to those found in the usual human diet; however the formulation uses specific ratios of the key ingredients to elicit a therapeutic response. Patients with a viral disease may require an increased amount of certain amino acids that cannot be obtained from normal diet alone. Choline, for example, is an obligatory amino acid. The body cannot make choline and must obtain choline from the diet. Choline is required to fully potentiate nitric oxide synthesis in the nasal passage and lungs. A deficiency of choline leads to reduced nitric oxide production in the nasal passage and lungs. Flavonoids potentiate the production of nitric oxide in the nasal passage and lungs. Choline deficient diets and diets deficient in flavonoid rich foods can result in inadequate flavonoid concentrations, impeding nitric oxide production. Provision of arginine, choline, and flavonoids with antioxidants, in specific proportions can restore the production of beneficial nitric oxide, thereby inhibiting viral growth. Flavonoids Flavonoids are a group of phytochemical compounds found in all vascular plants including fruits and vegetables. They are a part of a larger class of compounds known as polyphenols. Many of the therapeutic or health benefits of colored fruits and vegetables, cocoa, red wine, and green tea are directly related to their flavonoid content. The specially formulated flavonoids found in Lister-V cannot be obtained from conventional foods in the necessary proportions to elicit a therapeutic response. Physical Description Lister-V is a yellow to light brown powder. Lister-V contains L-Arginine, L-Glutamic Acid, Lecithin, Echinacea Angustifolia, Green Tea Extract, Licorice Extract, Cinnamon, Cocoa, Hydrolyzed Whey Protein, Caffeine, Ginkgo Biloba, and Grape Seed Extract. Other Ingredients Lister-V contains the following inactive or other ingredients, as fillrs, excipients, and colorings: magnesium stearate, microcrystalline cellulose, Maltodextrin NF, gelatin (as the capsule material).
