Estradiol Patch, Extended Release
Product Images NDC 69238-1631

Product Visual Gallery

This gallery contains 26 technical images submitted to the FDA as part of the official labeling for Estradiol (NDC 69238-1631). Unlike standard consumer photos, these assets often include clinical data figures, molecular chemical structures, and official manufacturer packaging layouts.

As provided by Amneal Pharmaceuticals Ny Llc, these visuals offer a comprehensive scientific overview of the product's physical and chemical identity, aiding pharmacists and researchers in product verification and study.

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Structural Formula (Estradiol Transdermal System Usp Vivelle 1)

Chemical structure of Estradiol showing its steroid backbone with hydroxyl groups at specific positions, as a representation of the active ingredient in Estradiol transdermal patches by Amneal Pharmaceuticals.*

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Instructions 4a (Estradiol Transdermal System Usp Vivelle 10)

An instructional illustration showing two hands; one hand is peeling back a protective layer from a rectangular patch, indicating the removal process for the Estradiol transdermal extended-release patch.*

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Instructions 4b (Estradiol Transdermal System Usp Vivelle 11)

An instructional illustration showing hands peeling apart the protective liner of a transdermal patch. The image likely demonstrates how to prepare a patch for application on the skin.*

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Instructions 4c (Estradiol Transdermal System Usp Vivelle 12)

An instructional illustration depicting the application of a small circular transdermal patch onto the skin of the abdomen using fingers. The image suggests the proper placement of the Estradiol extended-release patch for transdermal delivery.*

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Instructions 4d (Estradiol Transdermal System Usp Vivelle 13)

An instructional illustration showing two hands applying a transdermal patch to the skin on the upper arm or shoulder area. One hand is holding the patch while the other is pressing it down to adhere it properly.*

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Instructions 4e (Estradiol Transdermal System Usp Vivelle 14)

An instructional illustration showing a close-up of two hands applying a small transdermal patch to the skin on the abdomen. One hand is holding the patch while the other is pressing it onto the skin, demonstrating how to properly place the patch.*

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Instructions 4f (Estradiol Transdermal System Usp Vivelle 15)

An instructional illustration showing a hand with an inset demonstrating placement of a small transdermal patch on the back of the wrist. This likely depicts the application site for the Estradiol extended-release transdermal patch.*

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Instructions 4g (Estradiol Transdermal System Usp Vivelle 16)

An instructional illustration showing a hand applying a small circular estradiol transdermal patch to the skin, demonstrating proper placement for the patch delivery system.*

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0.025 mg/day Pouch (Estradiol Transdermal System Usp Vivelle 17)

Label for Estradiol Transdermal System, USP delivering 0.025 mg/day, twice weekly. Contains one 1.89 cm² patch with 0.314 mg estradiol. Includes inactive ingredients acrylic adhesive, silicone adhesive, oleyl alcohol, povidone, and dipropylene glycol. Distributed by Amneal Pharmaceuticals LLC, Bridgewater, NJ. Storage and safety instructions noted.*

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0.025 mg/day Carton (Estradiol Transdermal System Usp Vivelle 18)

Packaging label for Estradiol Transdermal System USP 0.025 mg/day by Amneal Pharmaceuticals NY LLC. The label shows the product as a transdermal extended-release patch delivering 0.025 mg of estradiol per day. The label includes directions, dosage strength, and usage instructions, with branding and regulatory information.*

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0.0375 mg/day Pouch (Estradiol Transdermal System Usp Vivelle 19)

Drug facts label for Estradiol Transdermal System, USP delivering 0.0375 mg/day. The label includes contents information, inactive components such as acrylic adhesive and silicone adhesive, storage instructions, and distributor details for Amneal Pharmaceuticals LLC.*

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Active Component System (Estradiol Transdermal System Usp Vivelle 2)

An illustration showing a layered diagram of an estradiol transdermal patch. The layers are labeled as backing, adhesive containing estradiol, and protective liner from top to bottom.*

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0.0375 mg/day Carton (Estradiol Transdermal System Usp Vivelle 20)

Packaging label for Estradiol Transdermal System, USP 0.0375 mg/day patch by Amneal Pharmaceuticals NY LLC. The label includes patient instructions for application, dosage information, contents of 8 patches per package, and handling/storage instructions. The label indicates the product is Rx only and includes branding with the Amneal logo.*

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0.05 mg/day Pouch (Estradiol Transdermal System Usp Vivelle 21)

Label for Estradiol Transdermal System, USP 0.05 mg/day patch by Amneal Pharmaceuticals LLC. The label states the system delivers 0.05 mg/day of estradiol with a patch size of 3.78 cm² containing 0.627 mg of estradiol. It includes storage instructions, inactive components, and a barcode.*

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0.05 mg/day Carton (Estradiol Transdermal System Usp Vivelle 22)

Packaging label for Estradiol Transdermal System, USP 0.05 mg/day patch by Amneal Pharmaceuticals NY LLC. The label indicates the product delivers 0.05 mg per day and includes 8 systems in the package. Instructions for patient use, storage directions, and Rx-only status are visible, along with a barcode and website www.amneal.com.*

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0.075 mg/day Pouch (Estradiol Transdermal System Usp Vivelle 23)

Label for Estradiol Transdermal System, USP delivering 0.075 mg/day. The label states the system size as one 5.66 cm² patch containing 0.940 mg estradiol. It includes inactive components details, storage instructions, child safety warning, distribution by Amneal Pharmaceuticals LLC, and a barcode.*

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0.075 mg/day Carton (Estradiol Transdermal System Usp Vivelle 24)

Packaging label for Estradiol Transdermal System, USP 0.075 mg/day extended-release transdermal patch by Amneal Pharmaceuticals NY LLC. The label shows one patch system delivering 0.075 mg per day, including patient instructions, storage information, and usage directions. The box graphic includes barcode and website address www.amneal.com.*

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0.1 mg/day Pouch (Estradiol Transdermal System Usp Vivelle 25)

Label for Estradiol Transdermal System, USP 0.1 mg/day patch, delivering 0.1 mg/day of estradiol. The label lists contents as one 7.55 cm² system containing 1.253 mg estradiol, with inactive ingredients including various adhesives and polymers. Distributed by Amneal Pharmaceuticals LLC, Bridgewater, NJ. Includes storage and usage instructions.*

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0.1 mg/day Carton (Estradiol Transdermal System Usp Vivelle 26)

Packaging label for Estradiol Transdermal System, USP 0.1 mg/day patch by Amneal Pharmaceuticals NY LLC. The label includes dosage form as an extended-release patch, delivering 0.1 mg/day, with instructions for application and patient use. The label states the product is prescription only, includes 8 transdermal systems, and features branding with the Amneal logo.*

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1 (Estradiol Transdermal System Usp Vivelle 3)

A line graph depicting estradiol concentration (pg/mL) over time (days) for four different doses of Estradiol extended-release transdermal patches: 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, and 0.1 mg/day. Concentration increases initially and then stabilizes or slightly fluctuates across 4 days for each dose.*

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Figure (Estradiol Transdermal System Usp Vivelle 4)

A bar graph showing mean change from baseline over 12 weeks for Estradiol 0.0375 mg/day patch versus placebo. The black bars represent Estradiol with larger reduction values at weeks 4, 8, and 12 compared to the white placebo bars. Statistical significance is noted between Estradiol and placebo groups at each time point.*

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3 (Estradiol Transdermal System Usp Vivelle 5)

A line graph showing percent change from baseline over treatment duration in weeks (26, 52, 78, 104) for Estradiol doses (0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.1 mg/day) and placebo. Each dose is represented by a distinct line, indicating trends in response over time.*

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4 (Estradiol Transdermal System Usp Vivelle 6)

A line graph showing percent change from baseline over treatment duration in weeks (26, 52, 78, 104) for Estradiol extended release patches at dosages 0.1 mg/day, 0.05 mg/day, 0.0375 mg/day, 0.025 mg/day, and placebo. The graph includes statistical comparisons indicating significant differences of all Estradiol doses versus placebo, with data points represented by different symbols for each dose and placebo.*

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Instructions 1 (Estradiol Transdermal System Usp Vivelle 7)

This image shows part of the Estradiol Transdermal System patient instructions, listing options for days on which the patch should be changed. The specified day pairs include Sun/Wed, Mon/Thu, Tue/Fri, Wed/Sat, Thu/Sun, Fri/Mon, and Sat/Tue.*

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Instructions 2 (Estradiol Transdermal System Usp Vivelle 8)

An instructional illustration showing a hand applying a small circular transdermal patch onto the abdomen, demonstrating the proper placement method for a topical estradiol patch.*

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Instructions 3 (Estradiol Transdermal System Usp Vivelle 9)

* About these descriptions: Image descriptions on this page are generated by automated AI analysis of the product label images from the manufacturer's FDA label submission (SPL). They are provided for reference only and may contain errors or omissions. Always rely on the printed label itself and the official FDA labeling, and consult a pharmacist or healthcare professional with any questions about this product.