Estradiol Valerate Injection
Pricing Report NDC 70700-274-22

Current NADAC: $21.53868 per ML · Effective Aug 19, 2026 · Est. package price $107.69 (5 ML)
Table of Contents
  1. Current Pricing Information
  2. Pricing History

Current Package Pricing Information

The current wholesale acquisition cost for Estradiol Valerate (NDC 70700-274-22) is $21.53868 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Aug 19, 2026.

As a a human prescription drug provided by Xiromed, Llc, this medication is distributed in a 5 mL in 1 VIAL, MULTI-DOSE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$21.53868
Per ML

Pricing Unit
Per ML Pricing Unit
Indicates the billing unit (ML, GM or EA).
Effective Date
Aug 19, 2026
Billable Units
5 ML
Estimated Package Price
$107.69
Data Status
As of Sep 09, 2026
Pharmacy Source Pharmacy Type Indicator
Data collected from Chain/Independent pharmacy surveys.
C/I - Chain or Independent Pharmacy
Rate Classification Classification for Rate Setting
Indicates if the NDC is Brand (B) or Generic (G).
G - Generic
Package NDC
70700-274-22
Description
5 mL in 1 VIAL, MULTI-DOSE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jul 2023, the NADAC wholesale price for (NDC ) has moved within a range of $13.56783 to $23.44422 per ML. Over this 3 years and 1 month period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$13.5678 - $23.4442
Market Volatility
72.79% Variance
Latest Trend
2.93%

Recent NADAC Price History

DateUnit PriceUnitSourceMethodRate
Aug 19, 2026 $21.53868 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2026 $20.92617 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2026 $20.90002 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2026 $21.00379 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2026 $21.48967 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2026 $22.37099 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2026 $23.44422 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2026 $22.53531 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $22.12627 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $21.27070 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $22.16703 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2025 $21.98702 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic

Earlier NADAC Price History

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.

Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: September 09, 2026