Xhance Spray, Metered
Pricing Report NDC 71143-375-01

Current NADAC: $40.83706 per ML · Effective Sep 23, 2026
Table of Contents
  1. Current Pricing Information
  2. Pricing History

Current Package Pricing Information

The current wholesale acquisition cost for Xhance (NDC 71143-375-01) is $40.83706 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Sep 23, 2026.

As a a human prescription drug provided by Optinose Us, Inc., this medication is distributed in a 1 BOTTLE in 1 CARTON / 120 SPRAY, METERED in 1 BOTTLE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$40.83706
Per ML

Pricing Unit
Per ML Pricing Unit
Indicates the billing unit (ML, GM or EA).
Effective Date
Sep 23, 2026
Data Status
As of Oct 07, 2026
Pharmacy Source Pharmacy Type Indicator
Data collected from Chain/Independent pharmacy surveys.
C/I - Chain or Independent Pharmacy
Rate Classification Classification for Rate Setting
Indicates if the NDC is Brand (B) or Generic (G).
B - Brand
Package NDC
71143-375-01
Description
1 BOTTLE in 1 CARTON / 120 SPRAY, METERED in 1 BOTTLE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Oct 2018, the NADAC wholesale price for (NDC ) has moved within a range of $26.77525 to $40.90128 per ML. Over this 7 years and 11 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$26.7753 - $40.9013
Market Volatility
52.76% Variance
Latest Trend
0.11%

Recent NADAC Price History

DateUnit PriceUnitSourceMethodRate
Sep 23, 2026 $40.83706 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 19, 2026 $40.88023 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 22, 2026 $40.86799 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 17, 2026 $40.87379 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 20, 2026 $40.86723 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 01, 2026 $40.90128 MLC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2026 $40.90128 MLC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2026 $40.90128 MLC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 17, 2025 $39.32853 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 19, 2025 $39.33174 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $39.33586 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 17, 2025 $39.32696 MLC/I - Chain or Independent PharmacyCode 1, 5B - Brand

Earlier NADAC Price History

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.

Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: October 07, 2026