Femring
NDC Package 72495-301-05

11-digit billing NDC: 72495030105
Table of Contents
    1. Package Information
    2. Frequently Asked Questions

Package Information

Femring (estradiol acetate) rings is femring is contraindicated in women with any of the following conditions:•Undiagnosed abnormal genital bleeding•Known, suspected, or history of breast cancer•Known or suspected estrogen-dependent neoplasia•Active DVT, PE, or history of these conditions•Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions•Known anaphylactic reaction or angioedema to Femring•Known liver impairment or disease•Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders•Known or suspected pregnancy. This formulation utilizes a ring delivery system. Marketed by Millicent Us, Inc., this product is identified by NDC 72495-301 and is authorized under FDA application NDA021367.

Identification & Billing

NDC Package Code
72495-301-05
Package Description
1 POUCH in 1 CARTON / 90 d in 1 POUCH
Product Code
72495-301
11-Digit Billing Format
72495030105

Clinical Specifications

Proprietary Name
Femring
Non-Proprietary Name
Estradiol Acetate
Substance Name
Estradiol Acetate
Dosage Form
Ring - A small circular object with a vacant circular center that is usually intended to be placed in the body by special inserters, where the medication is released, generally for localized effects.
Administration Route
Vaginal - Administration into the vagina.
Active Ingredient(s)
ESTRADIOL ACETATE .05 mg/d
Pharmacologic Class
Usage Information
Femring is contraindicated in women with any of the following conditions:•Undiagnosed abnormal genital bleeding•Known, suspected, or history of breast cancer•Known or suspected estrogen-dependent neoplasia•Active DVT, PE, or history of these conditions•Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions•Known anaphylactic reaction or angioedema to Femring•Known liver impairment or disease•Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders•Known or suspected pregnancy

Regulatory & Marketing

Labeler Name
Millicent Us, Inc.
Product Type
Human Prescription Drug
FDA Application #
NDA021367
Marketing Category
NDA - A product marketed under an approved New Drug Application.
Start Marketing Date
08-01-2026
Listing Expiration
12-31-2027
Exclude Flag
N
Sample Package
Yes

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 72495-301-05 identifies a specific commercial package of 1 pouch in 1 carton / 90 d in 1 pouch of Femring, a human prescription drug labeled by Millicent Us, Inc.. This ring is formulated for vaginal use and contains estradiol acetate as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Millicent Us, Inc. on August 01, 2026. The current certification is valid through December 31, 2027.

How is this Millicent Us, Inc. product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 72495030105. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-3-2)
72495-301-05
11-Digit CMS (5-4-2)
72495-0301-05

Note: The zero is added to the Product segment to maintain the 5-4-2 structure.