Ciprofloxacin Hydrochloride Solution
NDC Package 72888-102-22

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. Other Packages
    3. Frequently Asked Questions

Package Information

Ciprofloxacin Hydrochloride solution is ciprofloxacin ophthalmic Solution is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below:Corneal Ulcers:    Pseudomonas aeruginosa                              Serratia marcescens*                               Staphylococcus aureus                              Staphylococcus epidermidis                              Streptococcus pneumoniae                              Streptococcus(Viridans Group) * Conjunctivitis:     Haemophilus influenzae                             Staphylococcus aureus                             Staphylococcus epidermidis                             Streptococcus pneumoniae*Efficacy for this organism was studied in fewer than 10 infections. This formulation utilizes a solution delivery system. Marketed by Advagen Pharma Limited, this product is identified by NDC 72888-102 and is authorized under FDA application ANDA075928.

Identification & Billing

NDC Package Code
72888-102-22
Package Description
5 mL in 1 BOTTLE
Product Code
72888-102
11-Digit Billing Format
72888010222
Billing Unit
ML - Billing unit of "milliliter" is used when a product is measured by its liquid volume.
Units Per Package
5 ML
RxNorm Crosswalk
  • RxCUI: 309307 - ciprofloxacin HCl 0.3 % Ophthalmic Solution
  • RxCUI: 309307 - ciprofloxacin 3 MG/ML Ophthalmic Solution
  • RxCUI: 309307 - ciprofloxacin 0.3 % Ophthalmic Solution
  • RxCUI: 309307 - ciprofloxacin 3 MG/ML (as ciprofloxacin hydrochloride 3.5 MG/ML) Ophthalmic Solution

Clinical Specifications

Proprietary Name
Ciprofloxacin Hydrochloride
Non-Proprietary Name
Ciprofloxacin Hydrochloride
Substance Name
Ciprofloxacin Hydrochloride
Dosage Form
Solution - A clear, homogeneous liquid1 dosage form that contains one or more chemical substances dissolved in a solvent or mixture of mutually miscible solvents.
Administration Route
Ophthalmic - Administration to the external eye.
Active Ingredient(s)
CIPROFLOXACIN HYDROCHLORIDE 3 mg/mL
Pharmacologic Class
Usage Information
Ciprofloxacin ophthalmic Solution is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below:Corneal Ulcers:    Pseudomonas aeruginosa                              Serratia marcescens*                               Staphylococcus aureus                              Staphylococcus epidermidis                              Streptococcus pneumoniae                              Streptococcus(Viridans Group) * Conjunctivitis:     Haemophilus influenzae                             Staphylococcus aureus                             Staphylococcus epidermidis                             Streptococcus pneumoniae*Efficacy for this organism was studied in fewer than 10 infections.

Regulatory & Marketing

Labeler Name
Advagen Pharma Limited
Product Type
Human Prescription Drug
FDA Application #
ANDA075928
Marketing Category
ANDA - A product marketed under an approved Abbreviated New Drug Application.
Start Marketing Date
03-16-2022
Listing Expiration
12-31-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Other Available Packages

The following commercial packages are registered under the same Product NDC (72888-102). Click a package code to view its specific billing and regulatory data.

72888-102-21
2.5 mL in 1 BOTTLE
72888-102-23
10 mL in 1 BOTTLE

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 72888-102-22 identifies a specific commercial package of 5 ml in 1 bottle of Ciprofloxacin Hydrochloride, a human prescription drug labeled by Advagen Pharma Limited. This solution is formulated for ophthalmic use and contains ciprofloxacin hydrochloride as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Advagen Pharma Limited on March 16, 2022. The current certification is valid through December 31, 2026.

How is this Advagen Pharma Limited product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 72888010222. Quantities are measured in per "ml or milliliter", products billed per milliliter are usually products measured by liquid volume.. There are 5 total billable units per package. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-3-2)
72888-102-22
11-Digit CMS (5-4-2)
72888-0102-22

Note: The zero is added to the Product segment to maintain the 5-4-2 structure.