Difluprednate
Pricing Report NDC 76282-708-50

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

This product is EXCLUDED from the official NDC directory because the listing data was inactivated by the FDA.

The current wholesale acquisition cost for Difluprednate (NDC 76282-708-50) is $8.11021 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since May 20, 2026.

As a provided by Exelan Pharmaceuticals, Inc., this medication is distributed in a 1 BOTTLE in 1 CARTON / 5 mL in 1 BOTTLE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$8.11021
Per ML

Effective Date
May 20, 2026
Data Status
As of Jun 03, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 BOTTLE in 1 CARTON / 5 mL in 1 BOTTLE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jun 2022, the NADAC wholesale price for (NDC ) has moved within a range of $8.11021 to $25.23234 per ML. Over this 3 years and 11 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$8.1102 - $25.2323
Market Volatility
211.12% Variance
Latest Trend
5.92%
Date Unit Price Unit Source Method Rate
May 20, 2026 $8.11021 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2026 $8.62047 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2026 $9.58196 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2026 $9.78583 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2026 $10.45989 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $10.24834 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $10.04595 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $9.93078 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2025 $10.31657 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2025 $11.37530 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 23, 2025 $11.37214 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2025 $11.87703 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2025 $12.58675 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 23, 2025 $13.44516 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 19, 2025 $14.68478 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2025 $12.84711 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2025 $11.97284 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2024 $11.29596 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2024 $10.80212 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2024 $14.24752 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2024 $14.90329 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2024 $14.30106 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $9.79369 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $13.14109 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $12.14322 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $12.11942 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2024 $16.39792 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 21, 2024 $14.34200 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 17, 2024 $17.11877 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $17.14975 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 22, 2023 $18.28161 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $16.88210 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2023 $15.24307 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2023 $17.74047 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 19, 2023 $18.92492 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 21, 2023 $19.40848 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 17, 2023 $21.57208 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 19, 2023 $19.83523 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $20.97953 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 22, 2023 $22.43755 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2023 $17.07461 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2022 $15.46627 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2022 $17.26806 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2022 $19.53172 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2022 $21.27281 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2022 $24.45168 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $25.23234 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2022 $24.61235 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 01, 2022 $22.55746 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: June 17, 2026