Avopef Injection
NDC Package 83831-145-25

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. Frequently Asked Questions

Package Information

Avopef (etoposide) injection is etoposide is used to treat testicular cancer and certain forms of lung cancer (such as small cell lung cancer). This formulation utilizes a injection delivery system. Marketed by Avyxa Pharma, Llc, this product is identified by NDC 83831-145 and is authorized under FDA application NDA220200.

Identification & Billing

NDC Package Code
83831-145-25
Package Description
1 VIAL in 1 CARTON / 25 mL in 1 VIAL
Product Code
83831-145
11-Digit Billing Format
83831014525

Clinical Specifications

Proprietary Name
Avopef
Non-Proprietary Name
Etoposide
Substance Name
Etoposide
Dosage Form
Injection - A sterile preparation intended for parenteral use; five distinct classes of injections exist as defined by the USP.
Administration Route
Intravenous - Administration within or into a vein or veins.
Active Ingredient(s)
ETOPOSIDE 500 mg/25mL
Pharmacologic Class
Usage Information
Etoposide is used to treat testicular cancer and certain forms of lung cancer (such as small cell lung cancer). Etoposide works by slowing the growth of cancer cells.

Regulatory & Marketing

Labeler Name
Avyxa Pharma, Llc
Product Type
Human Prescription Drug
FDA Application #
NDA220200
Marketing Category
NDA - A product marketed under an approved New Drug Application.
Start Marketing Date
06-24-2026
Listing Expiration
12-31-2027
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 83831-145-25 identifies a specific commercial package of 1 vial in 1 carton / 25 ml in 1 vial of Avopef, a human prescription drug labeled by Avyxa Pharma, Llc. This injection is formulated for intravenous use and contains etoposide as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Avyxa Pharma, Llc on June 24, 2026. The current certification is valid through December 31, 2027.

What are the primary indications for this medication?

Etoposide is used to treat testicular cancer and certain forms of lung cancer (such as small cell lung cancer). Etoposide works by slowing the growth of cancer cells.

How is this Avyxa Pharma, Llc product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 83831014525. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-3-2)
83831-145-25
11-Digit CMS (5-4-2)
83831-0145-25

Note: The zero is added to the Product segment to maintain the 5-4-2 structure.