Depo-estradiol Injection
Pricing Report NDC 0009-0271-01

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Depo-estradiol (NDC 0009-0271-01) is $51.90841 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jul 01, 2026.

As a a human prescription drug provided by Pharmacia & Upjohn Company Llc, this medication is distributed in a 1 VIAL in 1 CARTON / 5 mL in 1 VIAL configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$51.90841
Per ML

Effective Date
Jul 01, 2026
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
B-ANDA - Abbreviated New Drug Application
Package NDC
Description
1 VIAL in 1 CARTON / 5 mL in 1 VIAL
Pricing Methodology Explanation
The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
The NADAC was calculated based on package size.
The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jul 2013, the NADAC wholesale price for (NDC ) has moved within a range of $8.25965 to $51.90841 per ML. Over this 13 years period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$8.2597 - $51.9084
Market Volatility
528.46% Variance
Latest Trend
5.00%
Date Unit Price Unit Source Method Rate
Jul 01, 2026 $51.90841 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 17, 2026 $49.43611 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 20, 2026 $49.38186 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2026 $49.35148 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2026 $49.35148 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2026 $49.35148 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Dec 17, 2025 $47.00185 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Nov 19, 2025 $47.01232 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 22, 2025 $46.99552 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Sep 17, 2025 $47.12810 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 15, 2025 $48.49655 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
May 15, 2025 $48.49655 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2025 $44.08777 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2025 $44.08777 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2025 $44.08777 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Dec 18, 2024 $40.08015 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2024 $38.87746 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2024 $38.87746 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2024 $38.87746 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 19, 2024 $35.52465 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
May 22, 2024 $35.54304 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2024 $35.59096 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2024 $35.59096 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2024 $35.59096 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2023 $32.35453 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2023 $32.35453 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2023 $32.35453 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2023 $29.56318 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2023 $29.56318 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2023 $29.56318 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2022 $26.87537 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2022 $26.87537 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 01, 2022 $26.87537 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2022 $24.43127 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2022 $24.43127 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2022 $24.43127 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 20, 2021 $22.20964 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 20, 2021 $22.20964 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2021 $22.29299 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2021 $22.29299 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 21, 2020 $22.18120 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 21, 2020 $22.18120 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2020 $22.02873 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2020 $22.02873 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2020 $22.02873 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 21, 2019 $20.13540 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Aug 21, 2019 $20.13540 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 17, 2018 $20.13811 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Oct 17, 2018 $20.13811 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $20.14021 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $20.14021 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2018 $20.14021 MLC/I - Chain or Independent PharmacyCode 4, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 19, 2017 $18.40331 MLC/I - Chain or Independent PharmacyCode 1, 5, 6B-ANDA - Abbreviated New Drug Application
Jul 19, 2017 $18.40331 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 01, 2017 $18.54642 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 01, 2017 $18.54642 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Feb 22, 2017 $17.66359 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Feb 22, 2017 $17.66359 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2017 $17.96653 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2017 $17.96653 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 01, 2016 $16.41753 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 01, 2016 $16.41753 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2016 $15.00181 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jan 01, 2016 $15.00181 MLC/I - Chain or Independent PharmacyCode 3, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 01, 2015 $13.04494 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Jun 01, 2015 $13.04494 MLC/I - Chain or Independent PharmacyCode 2, 5, 6B-ANDA - Abbreviated New Drug Application
Jun 01, 2015 $13.04494 MLC/I - Chain or Independent PharmacyCode 3, 5B-ANDA - Abbreviated New Drug Application
Mar 18, 2015 $11.91950 MLC/I - Chain or Independent PharmacyCode 1, 5B-ANDA - Abbreviated New Drug Application
Mar 18, 2015 $11.91950 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Feb 18, 2015 $11.73650 MLC/I - Chain or Independent PharmacyCode 3, 5B-ANDA - Abbreviated New Drug Application
Jan 01, 2015 $12.03538 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Jan 01, 2015 $12.03538 MLC/I - Chain or Independent PharmacyCode 3, 5B-ANDA - Abbreviated New Drug Application
Oct 22, 2014 $10.46537 MLC/I - Chain or Independent PharmacyCode 1, 5B-ANDA - Abbreviated New Drug Application
Oct 22, 2014 $10.46537 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Jun 01, 2014 $10.24326 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Jun 01, 2014 $10.24326 MLC/I - Chain or Independent PharmacyCode 3, 5B-ANDA - Abbreviated New Drug Application
May 21, 2014 $9.48362 MLC/I - Chain or Independent PharmacyCode 1, 5B-ANDA - Abbreviated New Drug Application
Feb 19, 2014 $9.71243 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Feb 19, 2014 $9.71243 MLC/I - Chain or Independent PharmacyCode 3, 5B-ANDA - Abbreviated New Drug Application
Jan 01, 2014 $9.49786 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application
Jan 01, 2014 $9.49786 MLC/I - Chain or Independent PharmacyCode 3, 5B-ANDA - Abbreviated New Drug Application
Jul 01, 2013 $8.25965 MLC/I - Chain or Independent PharmacyCode 2, 5B-ANDA - Abbreviated New Drug Application

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026