Difluprednate Ophthalmic Emulsion
Pricing Report NDC 0781-6000-78

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Difluprednate Ophthalmic (NDC 0781-6000-78) is $7.04791 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Sandoz Inc, this medication is distributed in a 1 BOTTLE in 1 CARTON / 5 mL in 1 BOTTLE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$7.04791
Per ML

Effective Date
Jun 17, 2026
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 BOTTLE in 1 CARTON / 5 mL in 1 BOTTLE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Dec 2021, the NADAC wholesale price for (NDC ) has moved within a range of $7.04791 to $33.30867 per ML. Over this 4 years and 5 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$7.0479 - $33.3087
Market Volatility
372.60% Variance
Latest Trend
13.10%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $7.04791 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 20, 2026 $8.11021 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 22, 2026 $8.62047 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 18, 2026 $9.58196 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 18, 2026 $9.78583 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 21, 2026 $10.45989 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 17, 2025 $10.24834 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 19, 2025 $10.04595 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 22, 2025 $9.93078 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 17, 2025 $10.31657 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 20, 2025 $11.37530 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 23, 2025 $11.37214 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 18, 2025 $11.87703 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 21, 2025 $12.58675 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 23, 2025 $13.44516 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 19, 2025 $14.68478 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 19, 2025 $12.84711 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 22, 2025 $11.97284 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 18, 2024 $11.29596 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 20, 2024 $10.80212 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 23, 2024 $14.24752 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 18, 2024 $14.90329 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 21, 2024 $14.30106 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 17, 2024 $9.79369 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 19, 2024 $13.14109 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 22, 2024 $12.14322 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 17, 2024 $12.11942 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 20, 2024 $16.39792 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 21, 2024 $14.34200 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 17, 2024 $17.11877 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 20, 2023 $17.14975 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 22, 2023 $18.28161 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 18, 2023 $16.88210 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 20, 2023 $15.24307 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 23, 2023 $17.74047 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 19, 2023 $18.92492 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 21, 2023 $19.40848 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 17, 2023 $21.57208 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 19, 2023 $19.83523 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 22, 2023 $20.97953 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 22, 2023 $22.43755 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 18, 2023 $17.07461 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 21, 2022 $15.46627 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 23, 2022 $17.26806 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 19, 2022 $19.53172 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 21, 2022 $21.27281 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Aug 17, 2022 $24.45168 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 20, 2022 $25.23234 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 22, 2022 $24.61235 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 18, 2022 $22.55746 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 20, 2022 $26.23374 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 23, 2022 $31.84694 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 23, 2022 $31.64358 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 19, 2022 $32.07378 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 22, 2021 $33.30867 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026