Difluprednate Ophthalmic Emulsion
Pricing Report NDC 0781-6000-78

Current NADAC: $8.91843 per ML · Effective Aug 19, 2026
Table of Contents
  1. Current Pricing Information
  2. Pricing History

Current Package Pricing Information

The current wholesale acquisition cost for Difluprednate Ophthalmic (NDC 0781-6000-78) is $8.91843 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Aug 19, 2026.

As a a human prescription drug provided by Sandoz Inc, this medication is distributed in a 1 BOTTLE in 1 CARTON / 5 mL in 1 BOTTLE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$8.91843
Per ML

Pricing Unit
Per ML Pricing Unit
Indicates the billing unit (ML, GM or EA).
Effective Date
Aug 19, 2026
Data Status
As of Sep 09, 2026
Pharmacy Source Pharmacy Type Indicator
Data collected from Chain/Independent pharmacy surveys.
C/I - Chain or Independent Pharmacy
Rate Classification Classification for Rate Setting
Indicates if the NDC is Brand (B) or Generic (G).
G - Generic
Package NDC
0781-6000-78
Description
1 BOTTLE in 1 CARTON / 5 mL in 1 BOTTLE
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Dec 2021, the NADAC wholesale price for (NDC ) has moved within a range of $7.04791 to $33.30867 per ML. Over this 4 years and 7 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$7.0479 - $33.3087
Market Volatility
372.60% Variance
Latest Trend
20.43%

Recent NADAC Price History

DateUnit PriceUnitSourceMethodRate
Aug 19, 2026 $8.91843 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jul 22, 2026 $7.40566 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jun 17, 2026 $7.04791 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 20, 2026 $8.11021 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Apr 22, 2026 $8.62047 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Mar 18, 2026 $9.58196 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Feb 18, 2026 $9.78583 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Jan 21, 2026 $10.45989 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Dec 17, 2025 $10.24834 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Nov 19, 2025 $10.04595 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Oct 22, 2025 $9.93078 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
Sep 17, 2025 $10.31657 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic

Earlier NADAC Price History

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.

Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: September 09, 2026