Methotrexate Injection
Pricing Report NDC 16729-277-30

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Methotrexate (NDC 16729-277-30) is $1.73898 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Accord Healthcare, Inc., this medication is distributed in a 1 VIAL in 1 CARTON / 2 mL in 1 VIAL configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$1.73898
Per ML

Effective Date
Jun 17, 2026
Data Status
As of Jul 08, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 VIAL in 1 CARTON / 2 mL in 1 VIAL
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since May 2014, the NADAC wholesale price for (NDC ) has moved within a range of $0.64504 to $3.19357 per ML. Over this 12 years and 1 month period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$0.6670 - $3.1936
Market Volatility
378.80% Variance
Latest Trend
2.12%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $1.73898 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2026 $1.77656 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2026 $1.72716 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2026 $1.73641 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2026 $1.63462 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2026 $1.60937 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $1.56004 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $1.58333 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $1.67175 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2025 $1.83795 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2025 $2.07173 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 23, 2025 $2.37823 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2025 $2.44186 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2025 $2.41608 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 23, 2025 $2.52133 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 19, 2025 $2.76825 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 19, 2025 $2.95053 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 22, 2025 $2.85691 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2024 $2.75332 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 20, 2024 $2.72714 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2024 $2.71472 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 18, 2024 $1.95955 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2024 $1.99140 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $0.80288 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2024 $1.86100 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $0.80288 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2024 $2.44700 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $0.82400 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2024 $1.79857 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $0.81582 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2024 $1.73190 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $2.34083 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2023 $2.34083 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Nov 22, 2023 $1.89000 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 18, 2023 $1.27200 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2023 $1.65375 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $1.93158 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 22, 2023 $1.93158 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Feb 22, 2023 $1.50615 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2023 $1.59500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2022 $1.56271 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2022 $1.52706 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2022 $1.31950 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2022 $1.52682 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2022 $1.58400 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2022 $1.56200 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2022 $1.44750 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2022 $0.68440 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2022 $0.68440 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
May 18, 2022 $1.56289 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2022 $1.44237 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 23, 2022 $1.55875 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 23, 2022 $1.56667 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 19, 2022 $1.61313 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 22, 2021 $1.53056 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 20, 2021 $1.48375 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 20, 2021 $1.48375 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Sep 22, 2021 $1.44944 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 21, 2021 $1.66500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 21, 2021 $1.66500 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jun 23, 2021 $1.38342 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 19, 2021 $1.53214 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 17, 2021 $1.64107 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 17, 2021 $1.64107 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Feb 17, 2021 $1.54500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 20, 2021 $1.86929 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 23, 2020 $2.05389 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 18, 2020 $2.65929 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 23, 2020 $2.26455 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 23, 2020 $2.26455 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jul 22, 2020 $2.86056 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2020 $2.86056 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jun 17, 2020 $1.93833 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2020 $1.89786 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2020 $0.79980 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2020 $0.79980 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Mar 18, 2020 $2.35800 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2020 $2.35800 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Dec 18, 2019 $3.19357 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 18, 2019 $3.19357 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Oct 23, 2019 $2.85583 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 23, 2019 $2.85583 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Sep 18, 2019 $2.87500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 21, 2019 $2.17133 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 17, 2019 $2.85792 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 19, 2019 $2.23071 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 22, 2019 $2.36125 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 17, 2019 $2.22050 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 20, 2019 $2.65286 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 20, 2019 $2.18464 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 23, 2019 $2.35000 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 19, 2018 $1.53042 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 21, 2018 $2.42727 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 17, 2018 $2.02579 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 19, 2018 $1.53853 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 22, 2018 $1.54857 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 18, 2018 $1.57700 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 20, 2018 $1.73143 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 23, 2018 $1.67000 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 18, 2018 $1.55417 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 21, 2018 $1.71750 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2017 $1.39000 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 20, 2017 $1.39000 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Nov 22, 2017 $1.44188 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2017 $0.71067 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2017 $0.71067 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Sep 20, 2017 $1.35900 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 20, 2017 $1.35900 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Aug 23, 2017 $0.77075 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 23, 2017 $1.20917 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2017 $1.45167 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 18, 2017 $1.45167 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Dec 21, 2016 $0.81415 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 21, 2016 $0.81415 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Dec 21, 2016 $1.45357 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2016 $0.91475 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 23, 2016 $1.40500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2016 $0.81967 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 19, 2016 $1.52647 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2016 $0.66700 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 21, 2016 $1.60167 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2016 $0.75750 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 17, 2016 $1.45071 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2016 $0.79757 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 20, 2016 $1.51857 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2016 $1.05180 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 22, 2016 $1.47789 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2016 $0.73960 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 18, 2016 $1.68395 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2016 $0.84925 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 20, 2016 $1.56938 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 23, 2016 $0.87391 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 23, 2016 $1.54500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 17, 2016 $0.88067 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 17, 2016 $1.56375 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 20, 2016 $1.50333 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 23, 2015 $0.82757 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 23, 2015 $0.82757 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Dec 23, 2015 $1.66500 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 18, 2015 $0.99933 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 18, 2015 $1.46400 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 21, 2015 $0.86920 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 21, 2015 $1.48800 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 23, 2015 $1.61917 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 19, 2015 $0.74186 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 19, 2015 $0.74186 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Aug 19, 2015 $1.64563 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2015 $0.85686 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2015 $1.73563 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2015 $1.11480 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2015 $1.68357 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2015 $0.99970 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2015 $1.47750 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2015 $0.85329 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2015 $1.64429 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2015 $0.76722 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2015 $1.44000 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2015 $0.77587 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2015 $1.46125 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2015 $0.81190 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2015 $1.51000 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2014 $0.72829 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2014 $0.77030 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2014 $0.64504 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2014 $0.64504 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Oct 22, 2014 $0.72471 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Sep 17, 2014 $0.81736 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2014 $0.82130 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2014 $1.48667 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 20, 2014 $1.48667 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
Jul 23, 2014 $0.73369 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 18, 2014 $0.74263 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2014 $0.82300 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2014 $1.95900 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 21, 2014 $1.95900 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
May 07, 2014 $0.85386 MLC/I - Chain or Independent PharmacyCode 4, 5, 6G - Generic
May 07, 2014 $1.95500 MLC/I - Chain or Independent PharmacyCode 1, 5, 6G - Generic
May 07, 2014 $0.91456 MLC/I - Chain or Independent PharmacyCode 4, 5G - Generic
May 07, 2014 $0.91456 MLC/I - Chain or Independent PharmacyCode 4, 5, 6G - Generic

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: July 08, 2026