Methotrexate Injection
Pricing Report NDC 16729-277-30

Current NADAC: $1.75625 per ML · Effective Aug 19, 2026

Current Package Pricing Information

The current wholesale acquisition cost for Methotrexate (NDC 16729-277-30) is $1.75625 per ML. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Aug 19, 2026.

As a a human prescription drug provided by Accord Healthcare, Inc., this medication is distributed in a 1 VIAL in 1 CARTON / 2 mL in 1 VIAL configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$1.75625
Per ML

Effective Date
Aug 19, 2026
Data Status
As of Sep 09, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 VIAL in 1 CARTON / 2 mL in 1 VIAL
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since May 2014, the NADAC wholesale price for (NDC ) has moved within a range of $0.64504 to $3.19357 per ML. Over this 12 years and 3 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$0.6670 - $3.1936
Market Volatility
378.80% Variance
Latest Trend
60.03%

Recent NADAC Price History

DateUnit PriceUnitSourceMethodRate
Aug 26, 2026 $0.70200 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Aug 19, 2026 $1.75625 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jul 22, 2026 $1.72153 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jun 17, 2026 $1.73898 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
May 20, 2026 $1.77656 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Apr 22, 2026 $1.72716 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Mar 18, 2026 $1.73641 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Feb 18, 2026 $1.63462 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Jan 21, 2026 $1.60937 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Dec 17, 2025 $1.56004 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Nov 19, 2025 $1.58333 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic
Oct 22, 2025 $1.67175 MLC/I - Chain or Independent PharmacyCode 1, 5G - Generic

Earlier NADAC Price History

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.
  • Code 6: The CMS Covered Outpatient File drug category type of S/I/N (Single Source/Innovator/Non-Innovator) has not been applied. Most S/I drugs with the same strength, dosage form and route of administration were grouped together for the purpose of the NADAC calculation and N drugs were also grouped together. In some cases, however, in calculating a NADAC, the CMS S/I/N designation was not applied when the state Medicaid brand or generic payment practices for these drugs generally differed from the CMS Covered Outpatient File designation.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: September 09, 2026