Hydrocortisone Valerate Cream
Pricing Report NDC 21922-007-06
Latest NADAC: $0.32921 per GM · Effective Nov 19, 2025 · Est. package price $14.81 (45 GM)
Current Package Pricing Information
The latest wholesale acquisition cost for Hydrocortisone Valerate Cream (NDC 21922-007-06) is $0.32921 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Nov 19, 2025.
As a a human prescription drug provided by Encube Ethicals, Inc., this medication is distributed in a 1 TUBE in 1 CARTON / 45 g in 1 TUBE configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.
NADAC Pricing Summary
NADAC pricing snapshot for this package NDC
Acquisition Cost $0.32921 Per GM
Pricing Unit
Effective Date
Nov 19, 2025
Billable Units
45 GM
Estimated Package Price
$14.81
Data Status
As of Nov 19, 2025
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.
The NADAC was calculated based on package size.
Historical Pricing Trends & Acquisition Cost Benchmarks
Since Dec 2022, the NADAC wholesale price for (NDC ) has moved within a range of $0.21200 to $0.76410 per GM. Over this 2 years and 11 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.
Price Range
$0.3635 - $0.7641
$0.3635 - $0.7641
Market Volatility
110.19% Variance
110.19% Variance
Latest Trend
9.26%
9.26%
Recent NADAC Price History
| Date | Unit Price | Unit | Source | Method | Rate |
|---|---|---|---|---|---|
| Nov 19, 2025 | $0.38899 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 19, 2025 | $0.32921 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 19, 2025 | $0.26269 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 22, 2025 | $0.42870 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 22, 2025 | $0.34750 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 22, 2025 | $0.25959 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 17, 2025 | $0.46201 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 17, 2025 | $0.35322 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 17, 2025 | $0.25276 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 20, 2025 | $0.48506 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 20, 2025 | $0.32135 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 20, 2025 | $0.25666 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
Earlier NADAC Price History
| Date | Unit Price | Unit | Source | Method | Rate |
|---|---|---|---|---|---|
| Jul 23, 2025 | $0.51398 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 23, 2025 | $0.28222 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 23, 2025 | $0.26800 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 18, 2025 | $0.63552 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 18, 2025 | $0.26449 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 18, 2025 | $0.27743 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 21, 2025 | $0.71996 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 21, 2025 | $0.25882 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 21, 2025 | $0.27810 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 23, 2025 | $0.73569 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 23, 2025 | $0.27277 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 23, 2025 | $0.27628 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 19, 2025 | $0.64331 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 19, 2025 | $0.29193 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 19, 2025 | $0.26056 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 19, 2025 | $0.52398 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 19, 2025 | $0.30546 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 19, 2025 | $0.25370 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 22, 2025 | $0.49175 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 22, 2025 | $0.32623 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 22, 2025 | $0.25685 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 18, 2024 | $0.49555 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 18, 2024 | $0.33051 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 18, 2024 | $0.29132 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 20, 2024 | $0.48447 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 20, 2024 | $0.34403 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Nov 20, 2024 | $0.28841 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 23, 2024 | $0.57157 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 23, 2024 | $0.33375 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 23, 2024 | $0.33721 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 18, 2024 | $0.53477 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 18, 2024 | $0.28200 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 18, 2024 | $0.33597 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 21, 2024 | $0.48806 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 21, 2024 | $0.23284 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 21, 2024 | $0.29622 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 17, 2024 | $0.45664 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 17, 2024 | $0.21200 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 17, 2024 | $0.30689 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 19, 2024 | $0.48412 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 19, 2024 | $0.22823 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 19, 2024 | $0.32268 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 22, 2024 | $0.49785 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 22, 2024 | $0.23068 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 22, 2024 | $0.32458 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 17, 2024 | $0.50783 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 17, 2024 | $0.23785 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 17, 2024 | $0.29651 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 20, 2024 | $0.66362 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 20, 2024 | $0.29725 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 20, 2024 | $0.36869 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 21, 2024 | $0.60975 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 21, 2024 | $0.24642 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 21, 2024 | $0.41833 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 17, 2024 | $0.49963 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 17, 2024 | $0.31837 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 17, 2024 | $0.62800 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 20, 2023 | $0.45139 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 20, 2023 | $0.32567 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 20, 2023 | $0.45226 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 18, 2023 | $0.49637 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 18, 2023 | $0.49637 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Oct 18, 2023 | $0.23278 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 18, 2023 | $0.23278 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Oct 18, 2023 | $0.46771 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Oct 18, 2023 | $0.46771 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Sep 20, 2023 | $0.76410 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Sep 20, 2023 | $0.44343 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Aug 23, 2023 | $0.59698 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 19, 2023 | $0.69988 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 19, 2023 | $0.30517 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 19, 2023 | $0.30517 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Jul 19, 2023 | $0.30342 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jul 19, 2023 | $0.30342 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Jun 21, 2023 | $0.66507 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jun 21, 2023 | $0.41803 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 17, 2023 | $0.55792 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| May 17, 2023 | $0.55792 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Apr 19, 2023 | $0.62022 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 19, 2023 | $0.51931 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 19, 2023 | $0.51931 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Apr 19, 2023 | $0.48172 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Apr 19, 2023 | $0.48172 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Mar 22, 2023 | $0.46548 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Mar 22, 2023 | $0.38072 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 22, 2023 | $0.56419 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Feb 22, 2023 | $0.63922 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Jan 18, 2023 | $0.36352 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 21, 2022 | $0.60422 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 21, 2022 | $0.58622 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 21, 2022 | $0.58622 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Dec 21, 2022 | $0.32852 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 21, 2022 | $0.32852 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
| Dec 14, 2022 | $0.62783 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 14, 2022 | $0.41911 | GM | C/I - Chain or Independent Pharmacy | Code 1, 5 | G - Generic |
| Dec 14, 2022 | $0.60604 | GM | C/I - Chain or Independent Pharmacy | Code 4, 5 | G - Generic |
Pricing Methodology Legend
- Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
- Code 4: The NADAC was carried forward from the previous file.
- Code 5: The NADAC was calculated based on package size.
Understanding NADAC Pricing Data
The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.
Important Price Distinction:
The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.
NADAC Pricing Data Last Updated on: September 09, 2026
