Premarin Cream
Pricing Report NDC 0046-0872-21

View Wholesale Price per Unit, Acquisition Costs, and Historic Pricing Trends

Current Package Pricing Information

The current wholesale acquisition cost for Premarin Vaginal (NDC 0046-0872-21) is $15.08277 per GM. This benchmark price is based on the National Average Drug Acquisition Cost (NADAC) and has been effective since Jun 17, 2026.

As a a human prescription drug provided by Wyeth Pharmaceuticals Llc, A Subsidiary Of Pfizer Inc., this medication is distributed in a 1 TUBE, WITH APPLICATOR in 1 CARTON / 30 g in 1 TUBE, WITH APPLICATOR configuration. The pricing data is derived from C/I - Chain or Independent Pharmacy surveys, reflecting the actual invoice prices paid by community pharmacies to drug wholesalers.

NADAC Pricing Summary

NADAC pricing snapshot for this package NDC

Acquisition Cost
$15.08277
Per GM

Effective Date
Jun 17, 2026
Billable Units
30 GM
Estimated Package Price
$452.48
Data Status
As of Jun 17, 2026
C/I - Chain or Independent Pharmacy
Package NDC
Description
1 TUBE, WITH APPLICATOR in 1 CARTON / 30 g in 1 TUBE, WITH APPLICATOR
Pricing Methodology Explanation
The NADAC was calculated using information from the most recently completed pharmacy survey.
The NADAC was calculated based on package size.

Historical Pricing Trends & Acquisition Cost Benchmarks

Since Jul 2013, the NADAC wholesale price for (NDC ) has moved within a range of $6.17330 to $15.09907 per GM. Over this 12 years and 11 months period, the pricing trend reflects the shifting acquisition costs reported by retail and chain pharmacies to the Centers for Medicare and Medicaid Services (CMS). The following interactive chart and historical table detail every recorded price adjustment based on these federal surveys.

Price Range
$6.1733 - $15.0991
Market Volatility
144.59% Variance
Latest Trend
0.01%
Date Unit Price Unit Source Method Rate
Jun 17, 2026 $15.08277 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 20, 2026 $15.08177 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 01, 2026 $15.09907 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2026 $15.09907 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2026 $15.09907 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 17, 2025 $14.70225 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 19, 2025 $14.70234 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 22, 2025 $14.70169 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 17, 2025 $14.70187 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 20, 2025 $14.69828 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 23, 2025 $14.70259 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 18, 2025 $14.70228 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 21, 2025 $14.70275 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 01, 2025 $14.73804 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2025 $14.73804 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2025 $14.73804 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Dec 18, 2024 $14.39262 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 20, 2024 $14.39682 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 23, 2024 $14.40222 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Sep 18, 2024 $14.40039 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Aug 21, 2024 $14.40892 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jul 17, 2024 $14.41015 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jun 19, 2024 $14.40663 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
May 22, 2024 $14.41168 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Jan 01, 2024 $14.37626 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2024 $14.37626 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2024 $14.37626 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 18, 2023 $13.95753 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 18, 2023 $13.95753 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2023 $13.95431 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2023 $13.95431 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2023 $13.95431 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Jan 01, 2022 $13.28970 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2022 $13.28970 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2022 $13.28970 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 20, 2021 $12.90262 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 20, 2021 $12.90262 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2021 $12.90752 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2021 $12.90752 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2021 $12.90752 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 21, 2020 $12.53145 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 21, 2020 $12.53145 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2020 $12.53859 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2020 $12.53859 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2020 $12.53859 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 23, 2019 $11.94151 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 23, 2019 $11.94151 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 15, 2019 $11.96617 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 15, 2019 $11.96617 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 15, 2019 $11.96617 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Oct 17, 2018 $11.39635 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Oct 17, 2018 $11.39635 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2018 $11.37564 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2018 $11.37564 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2018 $11.37564 GMC/I - Chain or Independent PharmacyCode 4, 5B - Brand
Nov 22, 2017 $11.04442 GMC/I - Chain or Independent PharmacyCode 1, 5B - Brand
Nov 22, 2017 $11.04442 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Feb 22, 2017 $11.05699 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Feb 22, 2017 $11.05699 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 18, 2017 $11.05466 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2017 $11.28929 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jun 01, 2016 $10.31560 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jun 01, 2016 $10.31560 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2016 $9.42598 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2016 $9.42598 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jun 01, 2015 $8.61284 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jun 01, 2015 $8.61284 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2015 $7.86992 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2015 $7.86992 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jun 01, 2014 $7.19108 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jun 01, 2014 $7.19108 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jan 01, 2014 $6.57074 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand
Jan 01, 2014 $6.57074 GMC/I - Chain or Independent PharmacyCode 3, 5B - Brand
Jul 01, 2013 $6.17330 GMC/I - Chain or Independent PharmacyCode 2, 5B - Brand

Pricing Methodology Legend

  • Code 1: The NADAC was calculated using information from the most recently completed pharmacy survey.
  • Code 2: The average acquisition cost of the most recent survey was within ± 2% of the current NADAC; therefore, the NADAC was carried forward from the previous file.
  • Code 3: The NADAC based on survey data has been adjusted to reflect changes in published pricing, or as a result of an inquiry to the help desk.
  • Code 4: The NADAC was carried forward from the previous file.
  • Code 5: The NADAC was calculated based on package size.

Understanding NADAC Pricing Data

The National Average Drug Acquisition Cost (NADAC) is compiled by the Centers for Medicare and Medicaid Services (CMS). This data is derived from random monthly surveys of more than 60,000 pharmacies across all 50 states.


Important Price Distinction:

The prices listed on this page represent the wholesale invoice price paid by pharmacies to acquire the drug. This is NOT the retail price paid by consumers at the pharmacy counter. Final patient costs typically include pharmacy markups, professional dispensing fees, and insurance adjustments.

NADAC Pricing Data Last Updated on: June 17, 2026