Caldolor Injection
NDC Package 66220-287-08

View Billable Units, 11-Digit Conversion Format, and RxNorm mappings
Table of Contents
    1. Package Information
    2. NDC HCPCS Crosswalk
    3. Other Packages
    4. Frequently Asked Questions

Package Information

Caldolor (ibuprofen) injection is ibuprofen is used to help relieve mild to moderate pain. This formulation utilizes a injection delivery system. Marketed by Cumberland Pharmaceuticals Inc., this product is identified by NDC 66220-287 and is authorized under FDA application NDA022348.

Identification & Billing

NDC Package Code
66220-287-08
Package Description
25 VIAL in 1 CARTON / 8 mL in 1 VIAL
Product Code
66220-287
11-Digit Billing Format
66220028708
Billing Unit
ML - Billing unit of "milliliter" is used when a product is measured by its liquid volume.
RxNorm Crosswalk

Clinical Specifications

Proprietary Name
Caldolor
Non-Proprietary Name
Ibuprofen
Substance Name
Ibuprofen
Dosage Form
Injection - A sterile preparation intended for parenteral use; five distinct classes of injections exist as defined by the USP.
Administration Route
Intravenous - Administration within or into a vein or veins.
Active Ingredient(s)
IBUPROFEN 800 mg/8mL
Pharmacologic Class
Usage Information
Ibuprofen is used to help relieve mild to moderate pain. When used with an opioid (such as morphine), it may be used to relieve moderate to severe pain. It is also used to reduce fever. Ibuprofen is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

Regulatory & Marketing

Labeler Name
Cumberland Pharmaceuticals Inc.
Product Type
Human Prescription Drug
FDA Application #
NDA022348
Marketing Category
NDA - A product marketed under an approved New Drug Application.
Start Marketing Date
06-11-2009
Listing Expiration
12-31-2026
Exclude Flag
N
Sample Package
No

Hierarchy Structure

Code Lineage

The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. A labeler might be a manufacturer, re-packager or re-labeler. The product information included in the NDC directory does not indicate that FDA has verified the information provided by the product labeler. Assigned NDC numbers are not in any way an indication of FDA approval of the product.

* Please review the full disclaimer at the bottom of this page.

Billing & HCPCS Mapping

To facilitate insurance claims and reimbursement, this drug package is mapped to specific HCPCS administrative codes. This crosswalk aligns clinical data with the billing standards used in ASP (Average Sales Price), AWP, and OPPS payment systems. Use the cards below to identify the correct billable units for provider claims.

J1741
Source: ASP
Ibuprofen injection
HCPCS Dosage 100 MG
Units / Pkg 200

Note for Medical Coders: These mappings are synthesized from various CMS datasets including OPPS, PrEP, and DAC (Data Analysis and Coding) contractors. Always confirm unit conversions against the current quarter's pricing files before final submission.

* Please review the full disclaimer at the bottom of this page.

Other Available Packages

The following commercial packages are registered under the same Product NDC (66220-287). Click a package code to view its specific billing and regulatory data.

66220-287-24
20 BAG in 1 CASE / 200 mL in 1 BAG (66220-287-11)

* Please review the full disclaimer at the bottom of this page.

Frequently Asked Questions

What is the distribution configuration for this product package?

The code 66220-287-08 identifies a specific commercial package of 25 vial in 1 carton / 8 ml in 1 vial of Caldolor, a human prescription drug labeled by Cumberland Pharmaceuticals Inc.. This injection is formulated for intravenous use and contains ibuprofen as the active substance.

Is this product currently listed with the FDA?

Yes, this product is active and verified within the NDC Directory. It was introduced to the market by Cumberland Pharmaceuticals Inc. on June 11, 2009. The current certification is valid through December 31, 2026.

What are the primary indications for this medication?

Ibuprofen is used to help relieve mild to moderate pain. When used with an opioid (such as morphine), it may be used to relieve moderate to severe pain. It is also used to reduce fever. Ibuprofen is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

How is this Cumberland Pharmaceuticals Inc. product billed for insurance claims?

For medical billing and reimbursement, this package follows the 11-digit CMS format: 66220028708. Quantities are measured in per "ml or milliliter", products billed per milliliter are usually products measured by liquid volume.. The table below illustrates the segment conversion from the 10-digit labeler code to the 11-digit provider format.

11-Digit Code Conversion

Billing payers usually require a 5-4-2 segment configuration. Below is the conversion from the 10-digit package format to the 11-digit billing format:

10-Digit Format (5-3-2)
66220-287-08
11-Digit CMS (5-4-2)
66220-0287-08

Note: The zero is added to the Product segment to maintain the 5-4-2 structure.